Yes, it's possible.
There may be situations like where we want to restrict user to change the selected value of a check box, especially on edit form pages,
After doing much googling, i found the following solutions.
Method -1
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Just add disabled="disabled" as attribute.
<input type="checkbox" disabled="disabled" checked="checked">
* The disadvantage is, while submitting this form, server page won't get the value from a disabled control.
Method - 2 - ( feasible method for me)
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Just add both [onclick="return false"] and [onkeydown="return false"] attributes.
<input type="checkbox" onclick="return false" onkeydown="return false" checked="checked" />
Thanks friends, hope this would be helpful in your development time.